Discovering Volatile Biomarkers for Phenotyping Lung Infections
The primary cause of morbidity and mortality for persons with cystic fibrosis (CF) is pulmonary damage from chronic bacterial lung infections, with Staphylococcus aureus and Pseudomonas aeruginosa responsible for 90% of all infections.
ASU professor Heather Bean will discuss the research that she and her team are doing that may contribute to more effective drugs to treat chronic lung infections associated with cystic fibrosis and COPD.
"During chronic infection, these pathogens acquire phenotypes, such as antibiotic resistance and mucoidy, that are significantly correlated to lung function decline. However, accurately diagnosing these phenotypes in the clinical microbiology laboratory is incredibly challenging due to rapid phenotypic switching by the bacteria once they are cultured outside of the lung environment," explained Bean.
"The aim of our work is to identify volatile biomarkers that can be used to determine infection etiology and detect antibiotic resistance and mucoidy phenotypes directly from patient specimens, without the need for laboratory culturing."
Dr. Bean is an assistant professor of biomedicine and biotechnology in ASU's School of Life Sciences, Colllege of Liberal Arts and Sciences, at Tempe campus.
This lecture is part of the Science and Mathematics Colloquium Series organized by science and mathematics faculty in the College of Integrative Sciences and Arts. Faculty and practitioners discuss their current research and field projects in the annual series, held throughout the academic year at the ASU Polytechnic campus.